Degranulation of surgical sites?

This question is directed mostly to the academics who contribute to this site. I am in my final year of my Masters degree in implantology and have been assigned to undertake a narrative review on the subject, “How important is degranulation of a surgical site prior to grafting, when should it occur, and which methods are most effective?” Does anyone have an opinion about the feasibility of such a topic? To do a narrative review there must be papers to review and I cannot find anything meaningful relating to these questions. My thoughts are that this is more of a research project, perhaps requiring animal studies where wounds are artificially produced. The healing of different sites (in the same animal) could then be studied after the various interventions (or non-interventions) were undertaken. Maiming animals does not appeal to me but any comments would be greatly appreciated.