Would you use PRGF in a Patient with Multiple Myeloma?
I have a patient who has been daignosed with Multiple Myeloma (Multiple myeloma is cancer of the plasma cells in bone marrow) and the Oncologist plans on using IV Zometa as part of the cancer treatment. She has asked us to remove any questionable teeth prior to initation of IV Zometa. Since PRGF is Plasma Rich in Growth Factors and Multiple Myeloma is a cancer of the Plasma Cells, would using PRGF in the extraction sites concentrate cancer cells in the jawbone? Â If the answer to the above question is yes, would the accelerated healing of using PRGF be worth the risk or should we just eliminate this from our protocol? Â Would there be any significant disadvantage if we do this?
9 Comments on Would you use PRGF in a Patient with Multiple Myeloma?
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Dr. dan
4/17/2012
umm why? What's the point? Just extract and let it be.
Osurg
4/17/2012
Do the extractions. Follow the same method as for pre radiation extractions. Do not use PRGF. As Dr. Dan has said " what's the point".
jon
4/17/2012
Just extract, why make this more complex when it is straightforward.
Alejandro Berg
4/23/2012
The American association of traumatology has released a study that shows that the use of prgf is quite a problem 2 out of 3 patients that had prgf developed some type of cancer in the next 3 years , specially older patients. i am guessimg a cancer patient is not a real candidate for this treatment.
Baker vinci
4/25/2012
There is relatively good cure rate for some multiple myeloma patients. Unfortunately, bisphosphonates are a commonly used adjunctive therapy. Bv
Bruce Burgess
4/25/2012
Plasma cells and blood plasma are two entirely different things. One does not come from the other. I agree that PGRF is not needed, but only because it complicates a simple thing.
Baker vinci
4/25/2012
Bruce took the words out of my mouth! I would suggest doing just a bit of reading, before you post a question like this. Bv
Dinos
5/5/2012
Since PRGF is an autologus graft from patient own blood with a concetrated amount of platelets 2-3 times I do not find any relation with carcinogenesis .
If you have any data from the American association of Traumatology , please give the exact title and referance to read the article . It is the only way to serve science and not to publish rumors .With kind regards Dinos OMF
Richard Hughes, DDS, FAAI
5/6/2012
According to the J of Oral Cancer, PRGF may help reduce the incidence or BRONJ. Yes, I agree do read your basic science books. There is a difference between plasma cells and platelets.
